Immungenetics AG

Developing effective treatments for devastating diseases: Neurodegeneration, Inflammation, Mitochondrial Dysfunctions, Aging

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Bischof, J., Muller, S., Borufka, L., Asghari, F., Moller, S., Holzhuter, S.A., Nizze, H., Ibrahim, S.M., Jaster, R., 2015.
Quantitative Trait Locus Analysis Implicates CD4+/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis, PloS one 10, e0136298.
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Frohlich, C., Zschiebsch, K., Groger, V., Paarmann, K., Steffen, J., Thurm, C., Schropp, E.M., Bruning, T., Gellerich, F., Radloff, M., Schwabe, R., Lachmann, I., Krohn, M., Ibrahim, S., Pahnke, J., 2015.
Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for alpha-Synucleinopathies, Molecular neurobiology.
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Wanek, T., Romermann, K., Mairinger, S., Stanek, J., Sauberer, M., Filip, T., Traxl, A., Kuntner, C., Pahnke, J., Bauer, F., Erker, T., Loscher, W., Muller, M., Langer, O., 2015.
Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography, Molecular pharmaceutics 12, 3214-3225.
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Budworth, H., Harris, F.R., Williams, P., Lee do, Y., Holt, A., Pahnke, J., Szczesny, B., Acevedo-Torres, K., Ayala-Pena, S., McMurray, C.T., 2015.
Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease, PLoS genetics 11, e1005267.
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van Beek, N., Patsatsi, A., Gupta, Y., Moller, S., Freitag, M., Lemcke, S., Recke, A., Zillikens, D., Schmidt, E., Ibrahim, S., 2015.
A family with atypical Hailey Hailey disease–is there more to the underlying genetics than ATP2C1?, PloS one 10, e0121253.
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Schauer, M., Kottek, T., Schonherr, M., Bhattacharya, A., Ibrahim, S.M., Hirose, M., Kohling, R., Fuellen, G., Schmitz, U., Kunz, M., 2015.
A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging, Oncotarget 6, 8552-8566.
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Lill, C.M., Rengmark, A., Pihlstrom, L., Fogh, I., Shatunov, A., Sleiman, P.M., Wang, L.S., Liu, T., Lassen, C.F., Meissner, E., Alexopoulos, P., Calvo, A., Chio, A., Dizdar, N., Faltraco, F., Forsgren, L., Kirchheiner, J., Kurz, A., Larsen, J.P., Liebsch, M., Linder, J., Morrison, K.E., Nissbrandt, H., Otto, M., Pahnke, J., Partch, A., Restagno, G., Rujescu, D., Schnack, C., Shaw, C.E., Shaw, P.J., Tumani, H., Tysnes, O.B., Valladares, O., Silani, V., van den Berg, L.H., van Rheenen, W., Veldink, J.H., Lindenberger, U., Steinhagen-Thiessen, E., Consortium, S., Teipel, S., Perneczky, R., Hakonarson, H., Hampel, H., von Arnim, C.A., Olsen, J.H., Van Deerlin, V.M., Al-Chalabi, A., Toft, M., Ritz, B., Bertram, L., 2015.
The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease, Alzheimer’s & dementia : the journal of the Alzheimer’s Association.
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Krohn, M., Bracke, A., Avchalumov, Y., Schumacher, T., Hofrichter, J., Paarmann, K., Frohlich, C., Lange, C., Bruning, T., von Bohlen Und Halbach, O., Pahnke, J., 2015.
Accumulation of murine amyloid-beta mimics early Alzheimer’s disease, Brain : a journal of neurology 138, 2370-2382.
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Hirose, M., Schilf, P., Benoit, S., Eming, R., Glaser, R., Homey, B., Kunz, M., Nebel, A., Peitsch, W.K., Pfohler, C., Sardy, M., Schreiber, S., Zillikens, D., Schmidt, E., Ibrahim, S.M., German, A.G.S.G., 2015.
Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population, Experimental dermatology 24, 715-717.
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Apostolova, I., Niedzielska, D., Derlin, T., Koziolek, E.J., Amthauer, H., Salmen, B., Pahnke, J., Brenner, W., Mautner, V.F., Buchert, R., 2015.
Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 35, 1304-1312.
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Prussmann, J., Prussmann, W., Recke, A., Rentzsch, K., Juhl, D., Henschler, R., Muller, S., Lamprecht, P., Schmidt, E., Csernok, E., Gorg, S., Stocker, W., Zillikens, D., Ibrahim, S.M., Ludwig, R.J., 2014.
Co-occurrence of autoantibodies in healthy blood donors, Experimental dermatology 23, 519-521.
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Pahnke, J., Langer, O., Krohn, M., 2014.
Alzheimer’s and ABC transporters–new opportunities for diagnostics and treatment, Neurobiology of disease 72 Pt A, 54-60.
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Pahnke, J., Frohlich, C., Paarmann, K., Krohn, M., Bogdanovic, N., Arsland, D., Winblad, B., 2014.
Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects, Archives of medical research 45, 738-743.
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Muller, S., Kruger, B., Lange, F., Bock, C.N., Nizze, H., Glass, A., Ibrahim, S.M., Jaster, R., 2014.
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice, PloS one 9, e102266.
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Muller, S., Kaiser, H., Kruger, B., Fitzner, B., Lange, F., Bock, C.N., Nizze, H., Ibrahim, S.M., Fuellen, G., Wolkenhauer, O., Jaster, R., 2014.
Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice, PloS one 9, e94494.
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Mohle, L., Parlog, A., Pahnke, J., Dunay, I.R., 2014.
Spinal cord pathology in chronic experimental Toxoplasma gondii infection, European journal of microbiology & immunology 4, 65-75.
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Lemcke, S., Muller, S., Moller, S., Schillert, A., Ziegler, A., Cepok-Kauffeld, S., Comabella, M., Montalban, X., Rulicke, T., Nandakumar, K.S., Hemmer, B., Holmdahl, R., Pahnke, J., Ibrahim, S.M., 2014.
Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene, The American journal of pathology 184, 2420-2429.
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Bernstein, H.G., Holzl, G., Dobrowolny, H., Hildebrandt, J., Trubner, K., Krohn, M., Bogerts, B., Pahnke, J., 2014.
Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary, Mechanisms of ageing and development 141-142, 12-21.
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Bar, F., Foh, B., Pagel, R., Schroder, T., Schlichting, H., Hirose, M., Lemcke, S., Klinger, A., Konig, P., Karsten, C.M., Buning, J., Lehnert, H., Fellermann, K., Ibrahim, S.M., Sina, C., 2014.
Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice, PloS one 9, e102347.
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Steder, M., Alla, V., Meier, C., Spitschak, A., Pahnke, J., Furst, K., Kowtharapu, B.S., Engelmann, D., Petigk, J., Egberts, F., Schad-Trcka, S.G., Gross, G., Nettelbeck, D.M., Niemetz, A., Putzer, B.M., 2013.
DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling, Cancer cell 24, 512-527.
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Ranea, L.M., de Castro Marques, A., Moller, S., Gupta, Y., Ibrahim, S.M., 2013.
Genetic control of spontaneous arthritis in a four-way advanced intercross line, PloS one 8, e75611.
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Pahnke, J., Frohlich, C., Krohn, M., Schumacher, T., Paarmann, K., 2013.
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain, Mechanisms of ageing and development 134, 506-515.
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Hofrichter, J., Krohn, M., Schumacher, T., Lange, C., Feistel, B., Walbroel, B., Heinze, H.J., Crockett, S., Sharbel, T.F., Pahnke, J., 2013.
Reduced Alzheimer’s disease pathology by St. John’s Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice, Current Alzheimer research 10, 1057-1069.
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Frohlich, C., Paarmann, K., Steffen, J., Stenzel, J., Krohn, M., Heinze, H.J., Pahnke, J., 2013.
Genomic background-related activation of microglia and reduced beta-amyloidosis in a mouse model of Alzheimer’s disease, European journal of microbiology & immunology 3, 21-27.
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Schumacher, T., Krohn, M., Hofrichter, J., Lange, C., Stenzel, J., Steffen, J., Dunkelmann, T., Paarmann, K., Frohlich, C., Uecker, A., Plath, A.S., Sommer, A., Bruning, T., Heinze, H.J., Pahnke, J., 2012.
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice, PloS one 7, e35613.
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Schmidt, A., Pahnke, J., 2012.
Efficient near-infrared in vivo imaging of amyoid-beta deposits in Alzheimer’s disease mouse models, Journal of Alzheimer’s disease : JAD 30, 651-664.
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Schiffmann, L., Schwarz, F., Linnebacher, M., Prall, F., Pahnke, J., Krentz, H., Vollmar, B., Klar, E., 2012.
A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer, World journal of surgical oncology 10, 95.
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Scheffler, K., Krohn, M., Dunkelmann, T., Stenzel, J., Miroux, B., Ibrahim, S., von Bohlen Und Halbach, O., Heinze, H.J., Walker, L.C., Gsponer, J.A., Pahnke, J., 2012.
Mitochondrial DNA polymorphisms specifically modify cerebral beta-amyloid proteostasis, Acta neuropathologica 124, 199-208.
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Gimsa, U., Kanitz, E., Otten, W., Tuchscherer, M., Tuchscherer, A., Ibrahim, S.M., 2012.
Tumour necrosis factor receptor deficiency alters anxiety-like behavioural and neuroendocrine stress responses of mice, Cytokine 59, 72-78.
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Ehler, J., Patejdl, R., Junghanss, C., Lehmitz, R., Pahnke, J., Grossmann, A., Vogelgesang, S., Bruggemann, M., Benecke, R., Zettl, U.K., 2012.
Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma, Clinical neurology and neurosurgery 114, 1102-1103.
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April 26/27th, 2012:
Immungenetics AG participated at the Friday’s panel in the Investment and Innovation in Healthcare Summit 2012 in Berlin
Pahnke et al.
„Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice“, in: The Journal of Clinical Investigation, Volume 121, issue 10
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Ibrahim et al.
Patent „INp4BB-Gen as a diagnostic- and prognsotic-marker for MS“,
DPMA 102010008827 dated Feb. 22nd, 2011 (PTC has been filed)
Pahnke et al.
Patentapplication „Usage of Thiethylperazine (Torecan) and Thiethylperazine-derivates …“,
DPMA 102010062810(PCT has been filed)
Ibrahim et al.
„Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease“, in: Human Molecular Genetics, 2005, Vol.14, No.14, pp.1977-1989
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Ibrahim et al.
„Association of a common polymorphism in the promoter of UCP2 with the susceptibility to Multiple Sclerosis“, in: Journal of Molecular Medicine, 2005, Vol.83, No.10, pp. 806-811
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Ibrahim et al.
„Uncoupling Protein 2 has protective function during experimental autoimmune encephalomyelitis”, American Journal of Pathology, 2006, Vol 168, No.5. pp. 1570-1575
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Ibrahim et al.
„Association of UCP2-866 G/A polymorphisms with chronic inflammatory diseases“, in: Genes and Immunity, 2009, No.10, pp. 601-605
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Ibrahim et al.
„Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis”, Brain, 2001, Vol 124: 1927-38
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Ibrahim et al.
„Gene-expression profile of collagen-induced arthritis” J Autoimmun, 2002, 18 (2): 159-67
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Ibrahim et al:
„Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation. Nat Immunol, 2004, Vol 5 (4): 380-7
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Ibrahim et al:
„Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process. J Neuroimmunol, 2004,151 (1-2):158-70
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Ibrahim et al:
„Identification of new quantitative trait loci in mice with collagen-induced arthritis. Arthritis Rheum, 2004 50 (11): 3721-8
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